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Current X-ray structural studies focus on oligonucleotides in single crystals and in poly oligonucleotides in fibres.

These structures are less regular. Whether or not the excursions from regularity are related to base sequences is a lively issue.

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More ambitiously - and perhaps more wisely - there are increasingly successful studies of DNA bound to histones and other proteins which will reveal specifically how variety and variability in the genetic material can be exploited biologically. Among all its other riches, Saenger's book makes us aware of these too.

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Principles of nucleic acid structure

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Principles of Nucleic Acid Structure

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Topics in Nucleic Acid Structure

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Principles of Nucleic Acid Structure by Wolfram Saenger

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Wolfram Saenger. New textbooks at all levels of chemistry appear with great regularity.


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Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research.